Ontology highlight
ABSTRACT:
SUBMITTER: Pan D
PROVIDER: S-EPMC5245964 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Pan Dongqing D Klare Kerstin K Petrovic Arsen A Take Annika A Walstein Kai K Singh Priyanka P Rondelet Arnaud A Bird Alexander W AW Musacchio Andrea A
eLife 20170106
Centromeres are unique chromosomal loci that promote the assembly of kinetochores, macromolecular complexes that bind spindle microtubules during mitosis. In most organisms, centromeres lack defined genetic features. Rather, they are specified epigenetically by a centromere-specific histone H3 variant, CENP-A. The Mis18 complex, comprising the Mis18α:Mis18β subcomplex and M18BP1, is crucial for CENP-A homeostasis. It recruits the CENP-A-specific chaperone HJURP to centromeres and primes it for C ...[more]