Ontology highlight
ABSTRACT:
SUBMITTER: Niikura Y
PROVIDER: S-EPMC4826857 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Niikura Yohei Y Kitagawa Risa R Kitagawa Katsumi K
Cell reports 20160324 1
The presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown. We previously reported that CENP-A K124 ubiquitylation, mediated by CUL4A-RBX1-COPS8 E3 ligase activity, is required for CENP-A deposition at the centromere. Here, we show that pre-existing ubiquitylated CENP-A is necessary for recruitment of newly synthesized CENP-A to the cen ...[more]