Ontology highlight
ABSTRACT:
SUBMITTER: Hane FT
PROVIDER: S-EPMC5247686 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Hane Francis T FT Li Tao T Smylie Peter P Pellizzari Raiili M RM Plata Jennifer A JA DeBoef Brenton B Albert Mitchell S MS
Scientific reports 20170120
The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our ...[more]