An oxygen sensitive self-decision making engineered CAR T-cell.
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ABSTRACT:
SUBMITTER: Juillerat A
PROVIDER: S-EPMC5247770 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
An oxygen sensitive self-decision making engineered CAR T-cell.
Juillerat Alexandre A Marechal Alan A Filhol Jean Marie JM Valogne Yannick Y Valton Julien J Duclert Aymeric A Duchateau Philippe P Poirot Laurent L
Scientific reports 20170120
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choice of targetable antigens. By fusing an oxygen sensitive subdomain of HIF1α to a CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of ce ...[more]
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