Ontology highlight
ABSTRACT:
SUBMITTER: Schuster CF
PROVIDER: S-EPMC5248971 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Schuster Christopher F CF Bellows Lauren E LE Tosi Tommaso T Campeotto Ivan I Corrigan Rebecca M RM Freemont Paul P Gründling Angelika A
Science signaling 20160816 441
Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmotic stresses. To survive an increase in osmolarity, bacteria immediately take up potassium ions and small organic compounds known as compatible solutes. The second messenger cyclic diadenosine monophosphate (c-di-AMP) reduces the ability of bacteria to withstand osmotic stress by binding to and inhibiting several proteins that promote potassium uptake. We identified OpuCA, the adenosine triphosphat ...[more]