Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5249199 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wang Qun Q Chen Yan Y Cvitkovic Romana R Pennini Meghan E ME Chang Chew Shun CS Pelletier Mark M Bonnell Jessica J Koksal Adem C AC Wu Herren H Dall'Acqua William F WF Stover C Kendall CK Xiao Xiaodong X
PloS one 20170120 1
Antibody therapy against antibiotics resistant Klebsiella pneumoniae infections represents a promising strategy, the success of which depends critically on the ability to identify appropriate antibody targets. Using a target-agnostic strategy, we recently discovered MrkA as a potential antibody target and vaccine antigen. Interestingly, the anti-MrkA monoclonal antibodies isolated through phage display and hybridoma platforms all recognize an overlapping epitope, which opens up important questio ...[more]