Ontology highlight
ABSTRACT:
SUBMITTER: Law PJ
PROVIDER: S-EPMC5253627 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Law Philip J PJ Sud Amit A Mitchell Jonathan S JS Henrion Marc M Orlando Giulia G Lenive Oleg O Broderick Peter P Speedy Helen E HE Johnson David C DC Kaiser Martin M Weinhold Niels N Cooke Rosie R Sunter Nicola J NJ Jackson Graham H GH Summerfield Geoffrey G Harris Robert J RJ Pettitt Andrew R AR Allsup David J DJ Carmichael Jonathan J Bailey James R JR Pratt Guy G Rahman Thahira T Pepper Chris C Fegan Chris C von Strandmann Elke Pogge EP Engert Andreas A Försti Asta A Chen Bowang B Filho Miguel Inacio da Silva MI Thomsen Hauke H Hoffmann Per P Noethen Markus M MM Eisele Lewin L Jöckel Karl-Heinz KH Allan James M JM Swerdlow Anthony J AJ Goldschmidt Hartmut H Catovsky Daniel D Morgan Gareth J GJ Hemminki Kari K Houlston Richard S RS
Scientific reports 20170123
B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. We explored genome-wide association studies of chronic lymphocytic leukaemia (CLL, N = 1,842), Hodgkin lymphoma (HL, N = 1,465) and multiple myeloma (MM, N = 3,790). We identified a novel pleiotrop ...[more]