Ontology highlight
ABSTRACT:
SUBMITTER: Went M
PROVIDER: S-EPMC6315026 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Went Molly M Sud Amit A Speedy Helen H Sunter Nicola J NJ Försti Asta A Law Philip J PJ Johnson David C DC Johnson David C DC Mirabella Fabio F Holroyd Amy A Li Ni N Orlando Giulia G Weinhold Niels N van Duin Mark M Chen Bowang B Mitchell Jonathan S JS Mansouri Larry L Juliusson Gunnar G Smedby Karin E KE Jayne Sandrine S Majid Aneela A Dearden Claire C Allsup David J DJ Bailey James R JR Pratt Guy G Pepper Chris C Fegan Chris C Rosenquist Richard R Kuiper Rowan R Stephens Owen W OW Bertsch Uta U Broderick Peter P Einsele Hermann H Gregory Walter M WM Hillengass Jens J Hoffmann Per P Jackson Graham H GH Jöckel Karl-Heinz KH Nickel Jolanta J Nöthen Markus M MM da Silva Filho Miguel Inacio MI Thomsen Hauke H Walker Brian A BA Broyl Annemiek A Davies Faith E FE Hansson Markus M Goldschmidt Hartmut H Dyer Martin J S MJS Kaiser Martin M Sonneveld Pieter P Morgan Gareth J GJ Hemminki Kari K Nilsson Björn B Catovsky Daniel D Allan James M JM Houlston Richard S RS
Blood cancer journal 20181221 1
The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (R<sub>g</sub> = 0.4, P = 0.0046). Furthermore, four of the 4 ...[more]