Ontology highlight
ABSTRACT:
SUBMITTER: Luo L
PROVIDER: S-EPMC5253658 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nature communications 20170118
Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in many cell types; however, additional mechanisms are required for specificity of inflammatory responses in innate immune cells. Here we show that SCIMP, an immune-restricted, transmembrane adaptor protein (TRAP), promotes selective proinflammatory ...[more]