Ontology highlight
ABSTRACT:
SUBMITTER: Blazevic A
PROVIDER: S-EPMC5256101 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170123
Ruthenium complexes are promising candidates for anticancer agents, especially NKP-1339 (sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)]), which is on the edge to clinical applications. The anticancer mechanism seems to be tightly linked to the redox chemistry but despite progress in human clinical trials the in vivo Ru oxidation state and the coordination of Ru remains unclear. The Ru-based anticancer drug NKP-1339 was studied applying XANES (Cl K- and Ru L<sub>2,3</sub>-edges) in tu ...[more]