CD4⁺ Foxp3⁺ T cells promote aberrant immunoglobulin G production and maintain CD8⁺ T-cell suppression during chronic liver disease.

ABSTRACT: Persistent hepatotropic viral infections are a common etiologic agent of chronic liver disease. Unresolved infection can be attributed to nonfunctional intrahepatic CD8+ T-cell responses. In light of dampened CD8⁺ T-cell responses, liver disease often manifests systemically as immunoglobulin (Ig)-related syndromes due to aberrant B-cell functions. These two opposing yet coexisting phenomena implicate the potential of altered CD4⁺ T-cell help. Elevated CD4⁺ forkhead box P3-positive (Foxp3+) T cells were evident in both human liver disease and a mouse model of chemically induced liver injury despite marked activation and spontaneous IgG production by intrahepatic B cells. While this population suppressed CD8⁺ T-cell responses, aberrant B-cell activ

SUBMITTER: Tedesco D 

PROVIDER: S-EPMC5258825 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature