Ontology highlight
ABSTRACT:
SUBMITTER: Sumit M
PROVIDER: S-EPMC5259548 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Integrative biology : quantitative biosciences from nano to macro 20170101 1
Temporally modulated input mimics physiology. This chemical communication strategy filters the biochemical noise through entrainment and phase-locking. Under laboratory conditions, it also expands the observability space for downstream responses. A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs ...[more]