Ontology highlight
ABSTRACT:
SUBMITTER: Olson X
PROVIDER: S-EPMC5259754 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Olson Xiaoping X Kotani Shohei S Padilla Jennifer E JE Hallstrom Natalya N Goltry Sara S Lee Jeunghoon J Yurke Bernard B Hughes William L WL Graugnard Elton E
ACS synthetic biology 20160302 1
DNA strand displacement systems have transformative potential in synthetic biology. While powerful examples have been reported in DNA nanotechnology, such systems are plagued by leakage, which limits network stability, sensitivity, and scalability. An approach to mitigate leakage in DNA nanotechnology, which is applicable to synthetic biology, is to introduce mismatches to complementary fuel sequences at key locations. However, this method overlooks nuances in the secondary structure of the fuel ...[more]