Multiple functions of USP18.
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ABSTRACT:
SUBMITTER: Honke N
PROVIDER: S-EPMC5260889 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Multiple functions of USP18.
Honke Nadine N Shaabani Namir N Zhang Dong-Er DE Hardt Cornelia C Lang Karl S KS
Cell death & disease 20161103 11
Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, several functions of USP18 have been discovered: this protein is not only an isopeptidase but also a potent inhibitor of interferon signaling. Therefore, USP18 functions as 'a' maestro of many biological ...[more]
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