Ontology highlight
ABSTRACT:
SUBMITTER: Byrne AJ
PROVIDER: S-EPMC5266556 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Byrne A J AJ Weiss M M Mathie S A SA Walker S A SA Eames H L HL Saliba D D Lloyd C M CM Udalova I A IA
Mucosal immunology 20161019 3
Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of the expression of proinflammatory cytokine and responses to infection, but its role in regulating pulmonary immune responses to allergen is unknown. We used genetic ablation, adenoviral vector-driven overexpression, and adoptive transfer approaches to interrogate the role of IRF5 in pulmonary immunity and during challenge with the aeroallergen, house dust mite. Global IRF5 deficiency resulted in impair ...[more]