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Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study.


ABSTRACT: Hyponatremia is a frequent electrolyte disorder in HIV-infected patients with a prevalence of up to 56% in the pre-cART era. Several studies have demonstrated that patients with hyponatremia are at an increased risk of death. We aimed to investigate the prevalence of hyponatremia in the recent cART-era and evaluate its association with mortality.Single-center retrospective cohort study. A total of 1196 newly diagnosed and cART-naïve HIV patients followed at the AIDS Reference Center, St Pierre University Hospital in Brussels, Belgium, between 1 January 1998 and 31 December 2013 were included. Hyponatremia was defined as a baseline natremia lower than 135 mmol/l. The outcome of interest was the occurrence of death.In this study 177 (14.8%) patients had hyponatremia at baseline with a median natremia of 132.0 mmol/l [interquartile range (IQR) 130.0-134.0 mmol/l]. Hyponatremic patients had a lower CD4 cell count (207.5?±?197.7/?l vs 400.4?±?277.0/?l; P?

SUBMITTER: Braconnier P 

PROVIDER: S-EPMC5267411 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study.

Braconnier Philippe P   Delforge Marc M   Garjau Maria M   Wissing Karl Martin KM   De Wit Stéphane S  

BMC infectious diseases 20170126 1


<h4>Background</h4>Hyponatremia is a frequent electrolyte disorder in HIV-infected patients with a prevalence of up to 56% in the pre-cART era. Several studies have demonstrated that patients with hyponatremia are at an increased risk of death. We aimed to investigate the prevalence of hyponatremia in the recent cART-era and evaluate its association with mortality.<h4>Methods</h4>Single-center retrospective cohort study. A total of 1196 newly diagnosed and cART-naïve HIV patients followed at the  ...[more]

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