Ontology highlight
ABSTRACT:
SUBMITTER: Nonomura K
PROVIDER: S-EPMC5267560 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nonomura Keiko K Woo Seung-Hyun SH Chang Rui B RB Gillich Astrid A Qiu Zhaozhu Z Francisco Allain G AG Ranade Sanjeev S SS Liberles Stephen D SD Patapoutian Ardem A
Nature 20161221 7636
Respiratory dysfunction is a notorious cause of perinatal mortality in infants and sleep apnoea in adults, but the mechanisms of respiratory control are not clearly understood. Mechanical signals transduced by airway-innervating sensory neurons control respiration; however, the physiological significance and molecular mechanisms of these signals remain obscured. Here we show that global and sensory neuron-specific ablation of the mechanically activated ion channel Piezo2 causes respiratory distr ...[more]