Ontology highlight
ABSTRACT:
SUBMITTER: Hel Z
PROVIDER: S-EPMC5268400 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Hel Zdenek Z Xu Jun J Denning Warren L WL Helton E Scott ES Huijbregts Richard P H RP Heath Sonya L SL Overton E Turner ET Christmann Benjamin S BS Elson Charles O CO Goepfert Paul A PA Mestecky Jiri J
PLoS pathogens 20170126 1
HIV-1 infection is associated with an early and profound depletion of mucosal memory CD4+ T cells, a population that plays an indispensable role in the regulation of isotype switching and transepithelial transport of antibodies. In this study, we addressed whether the depletion of CD4+ T cell in HIV-1-infected individuals results in altered humoral responses specific to antigens encountered at mucosal surfaces. Comprehensive protein microarray of systemic humoral responses to intestinal microbio ...[more]