Ontology highlight
ABSTRACT:
SUBMITTER: Totzeck F
PROVIDER: S-EPMC5268486 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Totzeck Franziska F Andrade-Navarro Miguel A MA Mier Pablo P
PloS one 20170126 1
Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by ana ...[more]