Ontology highlight
ABSTRACT:
SUBMITTER: O'Farrell AC
PROVIDER: S-EPMC5271313 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
O'Farrell Alice C AC Evans Rhys R Silvola Johanna M U JM Miller Ian S IS Conroy Emer E Hector Suzanne S Cary Maurice M Murray David W DW Jarzabek Monika A MA Maratha Ashwini A Alamanou Marina M Udupi Girish Mallya GM Shiels Liam L Pallaud Celine C Saraste Antti A Liljenbäck Heidi H Jauhiainen Matti M Oikonen Vesa V Ducret Axel A Cutler Paul P McAuliffe Fionnuala M FM Rousseau Jacques A JA Lecomte Roger R Gascon Suzanne S Arany Zoltan Z Ky Bonnie B Force Thomas T Knuuti Juhani J Gallagher William M WM Roivainen Anne A Byrne Annette T AT
PloS one 20170127 1
Sunitinib is a tyrosine kinase inhibitor approved for the treatment of multiple solid tumors. However, cardiotoxicity is of increasing concern, with a need to develop rational mechanism driven approaches for the early detection of cardiac dysfunction. We sought to interrogate changes in cardiac energy substrate usage during sunitinib treatment, hypothesising that these changes could represent a strategy for the early detection of cardiotoxicity. Balb/CJ mice or Sprague-Dawley rats were treated o ...[more]