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Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

ABSTRACT: Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and (19)F MRI sensitivity was discovered as a novel theranostic agent.

SUBMITTER: Shi Q

PROVIDER: S-EPMC5271582 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Shi Qiuyan Q Li Yu Y Bo Shaowei S Li Xiaofei X Zhao Peng P Liu Qi Q Yang Zhigang Z Cong Hengjiang H Deng Hexiang H Chen Mingnan M Chen Shizhen S Zhou Xin X Ding Hong H Jiang Zhong-Xing ZX

Chemical communications (Cambridge, England) 20160321 29

Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and (19)F MRI sensitivity was discovered as a novel theranostic agent. ...[more]

PMID: 26997457

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