Ontology highlight
ABSTRACT:
SUBMITTER: Schirmeister T
PROVIDER: S-EPMC5367020 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Marine drugs 20170303 3
The 6-epimer of the plakortide H acid (<b>1</b>), along with the endoperoxides plakortide E (<b>2</b>), plakortin (<b>3</b>), and dihydroplakortin (<b>4</b>) have been isolated from a sample of the Caribbean sponge <i>Plakortis halichondrioides</i>. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (<b>5</b>), as well as the esters plakortide E me ...[more]