Ontology highlight
ABSTRACT:
SUBMITTER: Laitaoja M
PROVIDER: S-EPMC5275728 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Laitaoja Mikko M Isoniemi Sari S Valjakka Jarkko J Mándity István M IM Jänis Janne J
Protein science : a publication of the Protein Society 20161026 2
Small zinc finger (ZnF) motifs are promising molecular scaffolds for protein design owing to their structural robustness and versatility. Moreover, their characterization provides important insights into protein folding in general. ZnF motifs usually possess an exceptional specificity and high affinity towards Zn(II) ion to drive folding. While the Zn(II) ion is canonically coordinated by two cysteine and two histidine residues, many other coordination spheres also exist in small ZnFs, all havin ...[more]