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Ultra-fast cell counters based on microtubular waveguides.


ABSTRACT: We present a radio-frequency impedance-based biosensor embedded inside a semiconductor microtube for the in-flow detection of single cells. An impedance-matched tank circuit and a tight wrapping of the electrodes around the sensing region, which creates a close, leakage current-free contact between cells and electrodes, yields a high signal-to-noise ratio. We experimentally show a twofold improved sensitivity of our three-dimensional electrode structure to conventional planar electrodes and support these findings by finite element simulations. Finally, we report on the differentiation of polystyrene beads, primary mouse T lymphocytes and Jurkat T lymphocytes using our device.

SUBMITTER: Bausch CS 

PROVIDER: S-EPMC5278506 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Ultra-fast cell counters based on microtubular waveguides.

Bausch Cornelius S CS   Heyn Christian C   Hansen Wolfgang W   Wolf Insa M A IM   Diercks Björn-Philipp BP   Guse Andreas H AH   Blick Robert H RH  

Scientific reports 20170130


We present a radio-frequency impedance-based biosensor embedded inside a semiconductor microtube for the in-flow detection of single cells. An impedance-matched tank circuit and a tight wrapping of the electrodes around the sensing region, which creates a close, leakage current-free contact between cells and electrodes, yields a high signal-to-noise ratio. We experimentally show a twofold improved sensitivity of our three-dimensional electrode structure to conventional planar electrodes and supp  ...[more]

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