Ontology highlight
ABSTRACT:
SUBMITTER: Kamath D
PROVIDER: S-EPMC5278692 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kamath Divya D Gregory Steven T ST O'Connor Michael M
Antimicrobial agents and chemotherapy 20170124 2
Ribosomal protein uS5 is an essential component of the small ribosomal subunit that is involved in subunit assembly, maintenance of translational fidelity, and the ribosome's response to the antibiotic spectinomycin. While many of the characterized uS5 mutations that affect decoding map to its interface with uS4, more recent work has shown that residues distant from the uS4-uS5 interface can also affect the decoding process. We targeted one such interface-remote area, the loop 2 region (residues ...[more]