Ontology highlight
ABSTRACT:
SUBMITTER: Liu N
PROVIDER: S-EPMC5279948 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Liu Nan N Yang Yaxiong Y Ge Lin L Liu Min M Colecraft Henry M HM Liu Xiaodong X
eLife 20170106
Inhibitions and antagonists of L-type Ca<sup>2+</sup> channels are important to both research and therapeutics. Here, we report C-terminus mediated inhibition (CMI) for Ca<sub>V</sub>1.3 that multiple motifs coordinate to tune down Ca<sup>2+</sup> current and Ca<sup>2+</sup> influx toward the lower limits determined by end-stage CDI (Ca<sup>2+</sup>-dependent inactivation). Among IQ<sub>V</sub> (preIQ<sub>3</sub>-IQ domain), PCRD and DCRD (proximal or distal C-terminal regulatory domain), spatia ...[more]