Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Z
PROVIDER: S-EPMC5280074 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Jiang Z Z Li F F Wan Y Y Han Z Z Yuan W W Cao L L Deng Y Y Peng X X Chen F F Fan X X Liu X X Dai G G Wang Y Y Zeng Q Q Shi Y Y Zhou Z Z Chen Y Y Xu W W Luo S S Chen S S Ye X X Mo X X Wu X X Li Y Y
Current molecular medicine 20160101 6
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. However, its precise role is not yet well understood. A yeast two-hybrid screen was performed using a human cDNA library to identify potential LASS5- interaction partners. One identified clone encodes succinate dehydrogenase subunit B (SDHB). Mammalian two-hybrid assays showed that LASS5 interacts with SDHB, and the result was also confirmed by GST pull-down ...[more]