Ontology highlight
ABSTRACT:
SUBMITTER: Ray P
PROVIDER: S-EPMC5282457 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Ray Partha P White Rebekah R RR
Journal of nucleic acids 20170117
Cell-SELEX is performed to select for cell binding aptamers. We employed an additional selection pressure by using RNAse to remove surface-binding aptamers and select for cell-internalizing aptamers. A common RNA sequence was identified from independent cell-SELEX procedures against two different pancreatic cancer cell lines, indicating a strong selection pressure towards this sequence from the large pool of other available sequences present in the aptamer library. The aptamer is not specific fo ...[more]