Ontology highlight
ABSTRACT:
SUBMITTER: Oh E
PROVIDER: S-EPMC5282553 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Oh Edward E Jeremian Richie R Oh Gabriel G Groot Daniel D Susic Miki M Lee KwangHo K Foy Kelly K Laird Peter W PW Petronis Arturas A Labrie Viviane V
Scientific reports 20170131
Transcriptional variation in histologically- and genetically- identical cells is a widespread phenomenon in tissues, yet the processes conferring this heterogeneity are not well understood. To identify contributing factors, we analyzed epigenetic profiles associated with the in vivo transcriptional gradient of the mouse lactase gene (Lct), which occurs in enterocytes along the proximal-to-distal axis of the small intestine. We found that epigenetic signatures at enhancer and promoter elements al ...[more]