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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.

ABSTRACT: Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish-Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (n?=?77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (p?

SUBMITTER: Pasanen A

PROVIDER: S-EPMC5282585 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.

Pasanen Anu A Karjalainen Minna K MK Bont Louis L Piippo-Savolainen Eija E Ruotsalainen Marja M Goksör Emma E Kumawat Kuldeep K Hodemaekers Hennie H Nuolivirta Kirsi K Jartti Tuomas T Wennergren Göran G Hallman Mikko M Rämet Mika M Korppi Matti M

Scientific reports 20170131

Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish-Swedish population of 217 children hospitalized for bronchiolitis ...[more]

PMID: 28139761

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