Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC2912644 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Human heredity 20100423 1
Genome-wide search for new disease variants, based on well-established variants, has a long history in linkage analysis but is less well-known in genetic case-control association studies. We developed a simple yet highly efficient conditional search method that can find new variants, which are associated with a disease only through epistatic interaction with another variant and do not necessarily have a direct association effect. Our approach is analogous to partitioning of chi(2) in a hierarchi ...[more]