Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi H
PROVIDER: S-EPMC5282831 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yamaguchi Hirofumi H Arakawa Satoko S Kanaseki Toku T Miyatsuka Takeshi T Fujitani Yoshio Y Watada Hirotaka H Tsujimoto Yoshihide Y Shimizu Shigeomi S
The EMBO journal 20160810 18
Autophagy is a cellular process that degrades subcellular constituents, and is conserved from yeast to mammals. Although autophagy is believed to be essential for living cells, cells lacking Atg5 or Atg7 are healthy, suggesting that a non-canonical degradation pathway exists to compensate for the lack of autophagy. In this study, we show that the budding yeast Saccharomyces cerevisiae, which lacks Atg5, undergoes bulk protein degradation using Golgi-mediated structures to compensate for autophag ...[more]