Ontology highlight
ABSTRACT:
SUBMITTER: Liao PC
PROVIDER: S-EPMC7391283 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Liao Pin-Chao PC Wolken Dana M Alessi DMA Serrano Edith E Srivastava Pallavi P Pon Liza A LA
Cell reports 20200701 2
The mitochondria-associated degradation pathway (MAD) mediates ubiquitination and degradation of mitochondrial outer membrane (MOM) proteins by the proteasome. We find that the MAD, but not other quality-control pathways including macroautophagy, mitophagy, or mitochondrial chaperones and proteases, is critical for yeast cellular fitness under conditions of paraquat (PQ)-induced oxidative stress in mitochondria. Specifically, inhibition of the MAD increases PQ-induced defects in growth and mitoc ...[more]