Ontology highlight
ABSTRACT:
SUBMITTER: Poore CP
PROVIDER: S-EPMC5283092 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Poore Charlene P CP Sundaram Jeyapriya R JR Pareek Tej K TK Fu Amy A Amin Niranjana N Mohamed Nur Ezan NE Zheng Ya-Li YL Goh Angeline X H AX Lai Mitchell K MK Ip Nancy Y NY Pant Harish C HC Kesavapany Sashi S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100601 25
Cyclin-dependent kinase 5 (Cdk5)-mediated phosphorylation plays an important role in proper synaptic function and transmission. Loss of Cdk5 activity results in abnormal development of the nervous system accompanied by massive disruptions in cortical migration and lamination, therefore impacting synaptic activity. The Cdk5 activator p35 associates with delta-catenin, the synaptic adherens junction protein that serves as part of the anchorage complex of AMPA receptor at the postsynaptic membrane. ...[more]