Noninvasive monitoring of cancer therapy induced activated T cells using [18F]FB-IL-2 PET imaging.
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ABSTRACT:
SUBMITTER: Hartimath SV
PROVIDER: S-EPMC5283633 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Noninvasive monitoring of cancer therapy induced activated T cells using [<sup>18</sup>F]FB-IL-2 PET imaging.
Hartimath S V SV Draghiciu O O van de Wall S S Manuelli V V Dierckx R A J O RA Nijman H W HW Daemen T T de Vries E F J EF
Oncoimmunology 20161118 1
Cancer immunotherapy urgently calls for methods to monitor immune responses at the site of the cancer. Since activated T lymphocytes may serve as a hallmark for anticancer responses, we targeted these cells using the radiotracer N-(4-[<sup>18</sup>F]fluorobenzoyl)-interleukin-2 ([<sup>18</sup>F]FB-IL-2) for positron emission tomography (PET) imaging. Thus, we noninvasively monitored the effects of local tumor irradiation and/or immunization on tumor-infiltrating and systemic activated lymphocyte ...[more]
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