Dataset Information

Airway wall thickness on HRCT scans decreases with age and increases with smoking.

ABSTRACT:

Background

To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range.

Methods

HRCT scans were performed in 99 subjects (48 never- and 51 current-smokers, median age 39 years [IQR 22 - 54], 57% males). The AWT at an internal perimeter of 10 mm (AWT Pi10) was calculated as an overall measurement of AWT, based on all measurements throughout the lungs. Extensive pulmonary function testing was performed in all subjects.

Results

Higher age was associated with a lower AWT Pi10 (b = -0.003, p < 0.001). Current-smokers had a higher AWT Pi10 than never-smokers (mean 0.49 mm versus 0.44 mm, p = 0.022). In multivariate analysis, age and current-smoking were independently associated with AWT Pi10 (age b = -0.002, p < 0.001, current-smoking b = 0.041, p = 0.021), whereas gender was not (b = 0.011, p = 0.552). Higher AWT Pi10 was associated with a lower FEV₁, FEV₁/FVC, FEF_25-75 and higher R5, R20 and X5.

Conclusions

AWT decreases with higher age, possibly reflecting structural changes of the airways. Additionally, current-smokers have a higher AWT, possibly due to remodeling or inflammation. Finally, higher AWT is associated with a lower level of pulmonary function, even in this population of healthy subjects.

Trial registration

This Study was registered at www.clinicaltrials.gov with number NCT00848406 on 19 February 2009.

SUBMITTER: Telenga ED

PROVIDER: S-EPMC5286807 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Airway wall thickness on HRCT scans decreases with age and increases with smoking.

Telenga Eef D ED Oudkerk Matthijs M van Ooijen Peter M A PM Vliegenthart Rozemarijn R Ten Hacken Nick H T NH Postma Dirkje S DS van den Berge Maarten M

BMC pulmonary medicine 20170201 1

<h4>Background</h4>To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range.<h4>Methods</h4>HRCT scans were performed in 99 subjects (48 never- and 51 current-smokers, median age 39 years [IQR 22 - 54], 57% males). The AWT at an internal perimeter of 10 mm (AWT Pi10) was calculat ...[more]

PMID: 28143620

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Dataset Information

Airway wall thickness on HRCT scans decreases with age and increases with smoking.

Background

Methods

Results

Conclusions

Trial registration

Publications

Airway wall thickness on HRCT scans decreases with age and increases with smoking.

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