Ontology highlight
ABSTRACT:
SUBMITTER: Avino S
PROVIDER: S-EPMC5288143 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Avino Silvia S De Marco Paola P Cirillo Francesca F Santolla Maria Francesca MF De Francesco Ernestina Marianna EM Perri Maria Grazia MG Rigiracciolo Damiano D Dolce Vincenza V Belfiore Antonino A Maggiolini Marcello M Lappano Rosamaria R Vivacqua Adele A
Oncotarget 20160801 33
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein estrogen receptor (GPER) and the collagen receptor discoidin domain 1 (DDR1) that are implicated in cancer progression. Here, we provide novel evidence regarding the molecular mechanisms through which IGF-I/IGF-IR signaling triggers a functional cross-talk with GPER and DDR1 i ...[more]