Ontology highlight
ABSTRACT:
SUBMITTER: Khoury SJ
PROVIDER: S-EPMC5288398 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Khoury Samia J SJ Rochon James J Ding Linna L Byron Margie M Ryker Kristin K Tosta Patti P Gao Wendy W Freedman Mark S MS Arnold Douglas L DL Sayre Peter H PH Smilek Dawn E DE
Multiple sclerosis (Houndmills, Basingstoke, England) 20160805 5
<h4>Background</h4>Costimulatory blockade of T lymphocytes with the CTLA4-Ig fusion protein abatacept could be an effective treatment for the immune-mediated neuroinflammatory disease relapsing-remitting multiple sclerosis (RRMS).<h4>Objective</h4>To evaluate efficacy and safety of abatacept in RRMS.<h4>Methods</h4>ACCLAIM (A Cooperative Clinical Study of Abatacept in Multiple Sclerosis) was a Phase II, randomized, double-blind, placebo-controlled, multi-center trial. In all, 65 of 123 planned p ...[more]