Ontology highlight
ABSTRACT:
SUBMITTER: Chandrasekaran S
PROVIDER: S-EPMC5289223 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chandrasekaran Sriram S Cokol-Cakmak Melike M Sahin Nil N Yilancioglu Kaan K Kazan Hilal H Collins James J JJ Cokol Murat M
Molecular systems biology 20160524 5
Combination antibiotic therapies are being increasingly used in the clinic to enhance potency and counter drug resistance. However, the large search space of candidate drugs and dosage regimes makes the identification of effective combinations highly challenging. Here, we present a computational approach called INDIGO, which uses chemogenomics data to predict antibiotic combinations that interact synergistically or antagonistically in inhibiting bacterial growth. INDIGO quantifies the influence ...[more]