Transcriptomics

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Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies


ABSTRACT: Intratumour heterogeneity provides a fuel for cancer evolution enabling tumour cell populations to adapt to selective pressures imposed by the tumour microenvironment or therapeutic interventions. To uncover functionally heterogeneous subpopulations of tumour cells with different treatment sensitivity and to understand how clonal lineage-dependent transcriptomic diveristy contributes, we developed WILDseq, a hihg-complexity expressed barcode library for simultanous mapping of each cells' clonal identity and transcriptional states.

ORGANISM(S): Mus musculus

PROVIDER: GSE218774 | GEO | 2022/11/26

REPOSITORIES: GEO

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