Ontology highlight
ABSTRACT:
SUBMITTER: Camacho KM
PROVIDER: S-EPMC5289372 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Camacho Kathryn M KM Menegatti Stefano S Vogus Douglas R DR Pusuluri Anusha A Fuchs Zoë Z Jarvis Maria M Zakrewsky Michael M Evans Michael A MA Chen Renwei R Mitragotri Samir S
Journal of controlled release : official journal of the Controlled Release Society 20160324
PEGylated liposomes have transformed chemotherapeutic use of doxorubicin by reducing its cardiotoxicity; however, it remains unclear whether liposomal doxorubicin is therapeutically superior to free doxorubicin. Here, we demonstrate a novel PEGylated liposome system, named DAFODIL (Doxorubicin And 5-Flurouracil Optimally Delivered In a Liposome) that inarguably offers superior therapeutic efficacies compared to free drug administrations. Delivery of synergistic ratios of this drug pair led to gr ...[more]