Ontology highlight
ABSTRACT:
SUBMITTER: Cui M
PROVIDER: S-EPMC5289851 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cui Mingxue M Wang Yi Y Cavaleri Jonathon J Kelson Taylor T Teng Yudong Y Han Min M
Genetics 20161214 2
Our understanding of the cellular mechanisms by which animals regulate their response to starvation is limited, despite the strong relevance of the problem to major human health issues. The L1 diapause of Caenorhabditis elegans, where first-stage larvae arrest in response to a food-less environment, is an excellent system to study this mechanism. We found, through genetic manipulation and lipid analysis, that biosynthesis of ceramide, particularly those with longer fatty acid side chains, critic ...[more]