Ontology highlight
ABSTRACT:
SUBMITTER: Shu L
PROVIDER: S-EPMC5290165 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Shu Lingling L Hoo Ruby L C RL Wu Xiaoping X Pan Yong Y Lee Ida P C IP Cheong Lai Yee LY Bornstein Stefan R SR Rong Xianglu X Guo Jiao J Xu Aimin A
Nature communications 20170127
The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes. We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli. A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after f ...[more]