Ontology highlight
ABSTRACT:
SUBMITTER: Ikeda K
PROVIDER: S-EPMC7399049 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ikeda Kenji K Yamada Tetsuya T
Frontiers in endocrinology 20200728
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient from mitochondrial respiration. There is much evidence that UCP1 is the center of BAT thermogenesis and systemic energy homeostasis. Recently, UCP1 independent thermogenic pathway identified in thermogenic adipocytes. Importantly, the thermogenic p ...[more]