SC83288 is a clinical development candidate for the treatment of severe malaria.
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ABSTRACT:
SUBMITTER: Pegoraro S
PROVIDER: S-EPMC5290327 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
SC83288 is a clinical development candidate for the treatment of severe malaria.
Pegoraro Stefano S Duffey Maëlle M Otto Thomas D TD Wang Yulin Y Rösemann Roman R Baumgartner Roland R Fehler Stefanie K SK Lucantoni Leonardo L Avery Vicky M VM Moreno-Sabater Alicia A Mazier Dominique D Vial Henri J HJ Strobl Stefan S Sanchez Cecilia P CP Lanzer Michael M
Nature communications 20170131
Severe malaria is a life-threatening complication of an infection with the protozoan parasite Plasmodium falciparum, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against severe malaria. Here we describe a medicinal chemistry program starting from amicarbalide that led to two compounds with optimized pharmacological and antiparasitic properties. SC81458 and the clinical development candidate, SC8328 ...[more]
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