Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
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ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC5341541 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Zhang Fei F Wei Hudie H Wang Xiaoxiao X Bai Yu Y Wang Pilin P Wu Jiawei J Jiang Xiaoyong X Wang Yugang Y Cai Haiyan H Xu Ting T Zhou Aiwu A
Cell discovery 20170307
The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we identified KN035, an anti-PD-L1 nanobody that can strongly induce T-cell responses and inhibit tumor growth. The crystal structures of KN035 complexed with PD-L1 and free PD-L1, solved here at 1.7 and 2.7 Å resolution, respectively, show that KN035 competes with PD-1 (programmed death protein 1) for the same flat surface on PD-L1, mainly through a ...[more]
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