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Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia.

ABSTRACT: Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in AML from biological and clinical standpoint. In this review, we will outline the recent advances in the methylome study of AML and overview the impacts of DNA methylation on AML diagnosis, treatment, and prognosis.

SUBMITTER: Li Y

PROVIDER: S-EPMC5290606 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia.

Li Yan Y Xu Qingyu Q Lv Na N Wang Lili L Zhao Hongmei H Wang Xiuli X Guo Jing J Chen Chongjian C Li Yonghui Y Yu Li L

Journal of hematology & oncology 20170202 1

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in AML from biological and clinical standpoint. In this review, we will outline the recent advances in the methylome study of AML and overview the impacts of DNA methylation on AML diagnosis, treatment, a ...[more]

PMID: 28153026

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Genome wide DNA methylation of pediatric acute myeloid leukemia

Project description:Genome wide DNA methylation of pediatric acute myeloid leukemia

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