APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article.

ABSTRACT: To investigate the effect of apolipoprotein E (APOE) gene polymorphism on the resting-state brain function, structure, and blood flow in healthy adults younger than 35 years, using multimodality magnetic resonance (MR) imaging.Seventy-six healthy adults (34 men, 23.7?±?2.8 y; 31 APOE ?4/?3 carriers, 31 ?3/?3 carriers, and 14 ?2/?3 carriers) were included. For resting-state functional MRI data, default mode network (DMN) and amplitude of low-frequency fluctuation maps were extracted and analyzed. Voxel-based morphometry, diffusion tensor imaging from structural imaging, and cerebral blood flow based on arterial spin labeling MR imaging were also analyzed. Correlation analysis was performed between the above mentioned brain parameters and neuropsychological tests.There were no differences in neuropsychological performances, amplitude of low-frequency fluctuation, gray/white matter volumes, fractional anisotropy, mean diffusivity, or whole brain cerebral blood flow among the 3 groups. As for DMN, the ?4/?3 group showed increased functional connectivities (FCs) in the left medial prefrontal cortex and bilateral posterior cingulate cortices/precuneus compared with the ?3/?3 group, and increased FCs in the left medial prefrontal cortex and right temporal lobe compared with the ?2/?3 group (P?

SUBMITTER: Su YY 

PROVIDER: S-EPMC5291594 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature