Ontology highlight
ABSTRACT:
SUBMITTER: Kong A
PROVIDER: S-EPMC5293043 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kong Augustine A Frigge Michael L ML Thorleifsson Gudmar G Stefansson Hreinn H Young Alexander I AI Zink Florian F Jonsdottir Gudrun A GA Okbay Aysu A Sulem Patrick P Masson Gisli G Gudbjartsson Daniel F DF Helgason Agnar A Bjornsdottir Gyda G Thorsteinsdottir Unnur U Stefansson Kari K
Proceedings of the National Academy of Sciences of the United States of America 20170117 5
Epidemiological and genetic association studies show that genetics play an important role in the attainment of education. Here, we investigate the effect of this genetic component on the reproductive history of 109,120 Icelanders and the consequent impact on the gene pool over time. We show that an educational attainment polygenic score, POLY<sub>EDU,</sub> constructed from results of a recent study is associated with delayed reproduction (P < 10<sup>-100</sup>) and fewer children overall. The e ...[more]