Genome-wide association study identifies 74 loci associated with educational attainment.
Ontology highlight
ABSTRACT:
SUBMITTER: Okbay A
PROVIDER: S-EPMC4883595 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study identifies 74 loci associated with educational attainment.
Okbay Aysu A Beauchamp Jonathan P JP Fontana Mark Alan MA Lee James J JJ Pers Tune H TH Rietveld Cornelius A CA Turley Patrick P Chen Guo-Bo GB Emilsson Valur V Meddens S Fleur W SF Oskarsson Sven S Pickrell Joseph K JK Thom Kevin K Timshel Pascal P de Vlaming Ronald R Abdellaoui Abdel A Ahluwalia Tarunveer S TS Bacelis Jonas J Baumbach Clemens C Bjornsdottir Gyda G Brandsma Johannes H JH Pina Concas Maria M Derringer Jaime J Furlotte Nicholas A NA Galesloot Tessel E TE Girotto Giorgia G Gupta Richa R Hall Leanne M LM Harris Sarah E SE Hofer Edith E Horikoshi Momoko M Huffman Jennifer E JE Kaasik Kadri K Kalafati Ioanna P IP Karlsson Robert R Kong Augustine A Lahti Jari J van der Lee Sven J SJ deLeeuw Christiaan C Lind Penelope A PA Lindgren Karl-Oskar KO Liu Tian T Mangino Massimo M Marten Jonathan J Mihailov Evelin E Miller Michael B MB van der Most Peter J PJ Oldmeadow Christopher C Payton Antony A Pervjakova Natalia N Peyrot Wouter J WJ Qian Yong Y Raitakari Olli O Rueedi Rico R Salvi Erika E Schmidt Börge B Schraut Katharina E KE Shi Jianxin J Smith Albert V AV Poot Raymond A RA St Pourcain Beate B Teumer Alexander A Thorleifsson Gudmar G Verweij Niek N Vuckovic Dragana D Wellmann Juergen J Westra Harm-Jan HJ Yang Jingyun J Zhao Wei W Zhu Zhihong Z Alizadeh Behrooz Z BZ Amin Najaf N Bakshi Andrew A Baumeister Sebastian E SE Biino Ginevra G Bønnelykke Klaus K Boyle Patricia A PA Campbell Harry H Cappuccio Francesco P FP Davies Gail G De Neve Jan-Emmanuel JE Deloukas Panos P Demuth Ilja I Ding Jun J Eibich Peter P Eisele Lewin L Eklund Niina N Evans David M DM Faul Jessica D JD Feitosa Mary F MF Forstner Andreas J AJ Gandin Ilaria I Gunnarsson Bjarni B Halldórsson Bjarni V BV Harris Tamara B TB Heath Andrew C AC Hocking Lynne J LJ Holliday Elizabeth G EG Homuth Georg G Horan Michael A MA Hottenga Jouke-Jan JJ de Jager Philip L PL Joshi Peter K PK Jugessur Astanand A Kaakinen Marika A MA Kähönen Mika M Kanoni Stavroula S Keltigangas-Järvinen Liisa L Kiemeney Lambertus A L M LA Kolcic Ivana I Koskinen Seppo S Kraja Aldi T AT Kroh Martin M Kutalik Zoltan Z Latvala Antti A Launer Lenore J LJ Lebreton Maël P MP Levinson Douglas F DF Lichtenstein Paul P Lichtner Peter P Liewald David C M DC Loukola Anu A Madden Pamela A PA Mägi Reedik R Mäki-Opas Tomi T Marioni Riccardo E RE Marques-Vidal Pedro P Meddens Gerardus A GA McMahon George G Meisinger Christa C Meitinger Thomas T Milaneschi Yusplitri Y Milani Lili L Montgomery Grant W GW Myhre Ronny R Nelson Christopher P CP Nyholt Dale R DR Ollier William E R WE Palotie Aarno A Paternoster Lavinia L Pedersen Nancy L NL Petrovic Katja E KE Porteous David J DJ Räikkönen Katri K Ring Susan M SM Robino Antonietta A Rostapshova Olga O Rudan Igor I Rustichini Aldo A Salomaa Veikko V Sanders Alan R AR Sarin Antti-Pekka AP Schmidt Helena H Scott Rodney J RJ Smith Blair H BH Smith Jennifer A JA Staessen Jan A JA Steinhagen-Thiessen Elisabeth E Strauch Konstantin K Terracciano Antonio A Tobin Martin D MD Ulivi Sheila S Vaccargiu Simona S Quaye Lydia L van Rooij Frank J A FJ Venturini Cristina C Vinkhuyzen Anna A E AA Völker Uwe U Völzke Henry H Vonk Judith M JM Vozzi Diego D Waage Johannes J Ware Erin B EB Willemsen Gonneke G Attia John R JR Bennett David A DA Berger Klaus K Bertram Lars L Bisgaard Hans H Boomsma Dorret I DI Borecki Ingrid B IB Bültmann Ute U Chabris Christopher F CF Cucca Francesco F Cusi Daniele D Deary Ian J IJ Dedoussis George V GV van Duijn Cornelia M CM Eriksson Johan G JG Franke Barbara B Franke Lude L Gasparini Paolo P Gejman Pablo V PV Gieger Christian C Grabe Hans-Jörgen HJ Gratten Jacob J Groenen Patrick J F PJ Gudnason Vilmundur V van der Harst Pim P Hayward Caroline C Hinds David A DA Hoffmann Wolfgang W Hyppönen Elina E Iacono William G WG Jacobsson Bo B Järvelin Marjo-Riitta MR Jöckel Karl-Heinz KH Kaprio Jaakko J Kardia Sharon L R SL Lehtimäki Terho T Lehrer Steven F SF Magnusson Patrik K E PK Martin Nicholas G NG McGue Matt M Metspalu Andres A Pendleton Neil N Penninx Brenda W J H BW Perola Markus M Pirastu Nicola N Pirastu Mario M Polasek Ozren O Posthuma Danielle D Power Christine C Province Michael A MA Samani Nilesh J NJ Schlessinger David D Schmidt Reinhold R Sørensen Thorkild I A TI Spector Tim D TD Stefansson Kari K Thorsteinsdottir Unnur U Thurik A Roy AR Timpson Nicholas J NJ Tiemeier Henning H Tung Joyce Y JY Uitterlinden André G AG Vitart Veronique V Vollenweider Peter P Weir David R DR Wilson James F JF Wright Alan F AF Conley Dalton C DC Krueger Robert F RF Davey Smith George G Hofman Albert A Laibson David I DI Medland Sarah E SE Meyer Michelle N MN Yang Jian J Johannesson Magnus M Visscher Peter M PM Esko Tõnu T Koellinger Philipp D PD Cesarini David D Benjamin Daniel J DJ
Nature 20160511 7604
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide signifi ...[more]